Article
Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism.
Molecular and cellular biology - 1 Aug 2002
Ross Sarah E, Erickson Robin L, Gerin Isabelle, DeRose Paul M, Bajnok Laszlo, Longo Kenneth A, Misek David E, Kuick Rork, Hanash Samir M, Atkins Kevin B, Andresen Sissel M, Nebb Hilde I, Madsen Lise, Kristiansen Karsten, MacDougald Ormond A
Abstract excerpt
Wnt signaling maintains preadipocytes in an undifferentiated state. When Wnt signaling is enforced, 3T3-L1 preadipocytes no longer undergo adipocyte conversion in response to adipogenic medium. Here we used microarray analyses to identify subsets of genes whose expression is aberrant when differentiation is blocked through enforced Wnt signaling. Furthermore, we used the microarray data to identify potentially...
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