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Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor

12 Jan 2017

Abstract excerpt

ABSTRACT The cytidine deaminase APOBEC3B (A3B) underlies the genetic heterogeneity of several human cancers, including cervical cancer, which is caused by human papillomavirus (HPV) infection. We previously identified a region within the A3B promoter that is activated by the viral protein HPV16 E6 in human keratinocytes. Here, we discovered three sites recognized by the TEAD family of transcription factors within...

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PMID: 28077648
DOI: 10.1128/jvi.02413-16

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