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Article

Vitamin C biosynthesis in trypanosomes: a role for the glycosome.

Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2005

Wilkinson Shane R, Prathalingam S Radhika, Taylor Martin C, Horn David, Kelly John M

Abstract excerpt

The capacity to synthesize vitamin C (ascorbate) is widespread in eukaryotes but is absent from humans. The last step in the biosynthetic pathway involves the conversion of an aldonolactone substrate to ascorbate, a reaction catalyzed by members of an FAD-dependent family of oxidoreductases. Here we demonstrate that both the African trypanosome, Trypanosoma brucei, and the American trypanosome, Trypanosoma cruzi,...

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Identifiers

PMID: 16087875
DOI: 10.1073/pnas.0504251102
PMCID: PMC1187986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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