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Article

Characterisation of an acapsular mutant of Burkholderia pseudomallei identified by signature tagged mutagenesis.

Journal of medical microbiology - 1 Jul 2002

Atkins Timothy, Prior Richard, Mack Kerri, Russell Paul, Nelson Michelle, Prior Joann, Ellis Jill, Oyston Petra C F, Dougan Gordon, Titball Richard W

Abstract excerpt

A Burkholderia pseudomallei mutant which was attenuated in a mouse model of melioidosis was identified by a signature tagged mutagenesis approach. The transposon was shown to be inserted into a gene within the capsular biosynthetic operon. Compared with the wild-type bacteria this mutant demonstrated a 10(5)-fold increase in the median lethal dose in a mouse model and it did not react with a monoclonal antibody...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12132769
DOI: 10.1099/0022-1317-51-7-539

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterisation of an acapsular mutant of Burkholderia pseudomallei identified by signature tagged mutagenesis.PMID 12132769Read ↗

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