Article
SIVmac pathogenesis in rhesus macaques of Chinese and Indian origin compared with primary HIV infections in humans
1 Jul 2002
Abstract excerpt
OBJECTIVE: To develop a SIV-rhesus macaque (Rh) model of AIDS that more closely approximates HIV pathogenesis in humans. DESIGN: The pathogenesis of SIV was compared in two different types of Rh, the Chinese (Ch) and Indian (Ind) subspecies. METHODS: Ch Rh and Ind Rh origin were identified genetically and infected with the SIV(mac)239 molecular clone. Plasma viral loads, depletion of intestinal lymphocytes with...
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