Article
Tramtrack69 is required for the early repression of tailless expression.
Mechanisms of development - 1 Aug 2002
Chen Yueh-Jung, Chiang Chuen-Sheue, Weng Li-Chuan, Lengyel Judith A, Liaw Gwo-Jen
Abstract excerpt
During embryogenesis, the activated Torso receptor tyrosine kinase (TOR RTK) pathway activates tailless (tll) expression by a relief-of-repression mechanism. Various lines of evidence have suggested that multiple factors are required for this repression. We show that Tramtrack69 (TTK69) binds to two sites within tll cis-regulatory DNA, TC2 and TC5, and that TTK69 is phosphorylated by mitogen activated protein...
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