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Article

Unliganded thyroid hormone receptor α regulates developmental timing via gene repression in Xenopus tropicalis.

Endocrinology - 1 Feb 2015

Choi Jinyoung, Suzuki Ken-Ichi T, Sakuma Tetsushi, Shewade Leena, Yamamoto Takashi, Buchholz Daniel R

Abstract excerpt

Thyroid hormone (TH) receptor (TR) expression begins early in development in all vertebrates when circulating TH levels are absent or minimal, yet few developmental roles for unliganded TRs have been established. Unliganded TRs are expected to repress TH-response genes, increase tissue responsivity to TH, and regulate the timing of developmental events. Here we examined the role of unliganded TRα in gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25456067
DOI: 10.1210/en.2014-1554
PMCID: PMC4298327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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