Article
Retinoic acid modulates the radiosensitivity of head-and-neck squamous carcinoma cells grown in collagen gel.
International journal of radiation oncology, biology, physics - 1 Aug 2002
Rossi Lorenzo, Corvò Renzo
Abstract excerpt
PURPOSE: Collagen gels are increasingly regarded as reliable scaffolds for studying cells in vitro, displaying the same three-dimensional network of collagen fibers as encountered in vivo. As a contribution to therapeutic control of head-and-neck cancer, we grew HSCO86 cells in collagen gel and assessed their behavior in the presence of retinoic acid (RA) and radiation. METHODS AND MATERIALS: The malignant...
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