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Article

Organotypic co-cultures allow for immortalized human gingival keratinocytes to reconstitute a gingival epithelial phenotype in vitro.

Differentiation; research in biological diversity - 1 Dec 2006

Roesch-Ely Mariana, Steinberg Thorsten, Bosch F Xavier, Müssig Eva, Whitaker Noel, Wiest Tina, Kohl Annette, Komposch Gerda, Tomakidi Pascal

Abstract excerpt

We report here that the organotypic co-culture (OCC) system allows for significant preservation of the tissue-specific phenotype of human gingival keratinocytes (IHGK) immortalized with the E6/E7 gene of the human papillomavirus type 16 (HPV16). The approach adopted is based on the OCC system facilitating spatially separated cell growth and cell-to-cell interactions via diffusible growth factors. Generally, IHGK...

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Identifiers

PMID: 17177858
DOI: 10.1111/j.1432-0436.2006.00099.x

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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