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Article

Ginkgo biloba for Tardive Dyskinesia and Plasma MnSOD Activity: Association with MnSOD Ala-9Val Variant: A Randomized, Double-blind Trial.

Current neuropharmacology - 1 Jan 2024

Wang Dongmei, Tian Yang, Chen Jiajing, Zhu Rongrong, Li Jiaxin, Zhou Huixia, Chen Dachun, Wang Li, Kosten Thomas R, Zhang Xiang-Yang

Abstract excerpt

BACKGROUND: Excessive free radicals are implicated in the pathophysiology of tardive dyskinesia (TD), and Ginkgo biloba extract (EGb761) scavenges free radicals, thereby enhancing antioxidant enzymes such as mitochondrial manganese superoxide dismutase (MnSOD). This study examined whether EGb761 treatment would improve TD symptoms and increase MnSOD activity, particularly in TD patients with specific MnSOD...

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PMID: 38919004
DOI: 10.2174/1570159X22666240530095721
PMCID: PMC11451319

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