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Article

Leptin is essential for the hepatic fibrogenic response to chronic liver injury.

Journal of hepatology - 1 Aug 2002

Leclercq Isabelle A, Farrell Geoffrey C, Schriemer Rixt, Robertson Graham R

Abstract excerpt

BACKGROUND/AIMS: Obesity is associated with hyperleptinemia and is also a risk factor for fibrosis and severity of fibrosis in several chronic liver diseases. The correlation between increased leptin, obesity and hepatic fibrosis prompted us to hypothesise that leptin has profibrogenic effects on the liver. METHODS: We analysed the role of leptin in liver fibrosis in leptin-deficient mice fed a diet which...

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PMID: 12127425
DOI: 10.1016/s0168-8278(02)00102-2

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.Semantic proximity Read ↗

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