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Article

Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells.

The Journal of biological chemistry - 26 Dec 2003

Hendrickx Nico, Volanti Cédric, Moens Ugo, Seternes Ole Morten, de Witte Peter, Vandenheede Jackie R, Piette Jacques, Agostinis Patrizia

Abstract excerpt

Photodynamic Therapy (PDT) is an approved anticancer therapy that kills cancer cells by the photochemical generation of reactive oxygen species following absorption of visible light by a photosensitizer, which selectively accumulates in tumors. We report that hypericin-mediated PDT of human cancer cells leads to up-regulation of the inducible cyclooxygenase-2 (COX-2) enzyme and the subsequent release of PGE2....

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PMID: 14557269
DOI: 10.1074/jbc.M307591200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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