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Article

Caenorhabditis elegans aristaless/Arx gene alr-1 restricts variable gene expression.

Proceedings of the National Academy of Sciences of the United States of America - 8 Mar 2011

Topalidou Irini, van Oudenaarden Alexander, Chalfie Martin

Abstract excerpt

Variable expressivity of mutant phenotypes in genetically identical individuals is a phenomenon widely reported but poorly understood. For example, mutations in the gene encoding the transcription factor ALR-1 in Caenorhabditis elegans result in variable touch receptor neuron (TRN) function. Using single-molecule in situ hybridization, we demonstrate that this phenotypic variability reflects enhanced variability...

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Identifiers

PMID: 21368126
DOI: 10.1073/pnas.1101329108
PMCID: PMC3053973

Genes

ARX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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