Article
The Epstein-Barr virus ZEBRA protein activates transcription from the early lytic F promoter by binding to a promoter-proximal AP-1-like site.
The Journal of general virology - 1 Aug 2002
Zetterberg Henrik, Jansson Ann, Rymo Lars, Chen Fu, Karlsson Ann, Klein Georg, Brodin Bertha
Abstract excerpt
The ZEBRA protein encoded by the Epstein-Barr virus (EBV) genome activates a switch from the latent to the lytic gene expression programme of the virus. ZEBRA, a member of the basic leucine zipper family of DNA-binding proteins, is a transcriptional activator capable of inducing expression from several virus lytic cycle promoters by binding to activator protein 1 (AP-1)-like sites. The Epstein-Barr virus BamHI F...
Topics
- B-Lymphocytes
- Cell Line
- Cell Line, Transformed
- DNA-Binding Proteins
- Deoxyribonuclease BamHI
- Gene Expression Regulation, Viral
- Genes, Reporter
- Genome, Viral
- Herpesvirus 4, Human
- Humans
- Phenotype
- Plasmids
- Promoter Regions, Genetic