Article
Differences in the extent of activation of Epstein-Barr virus replicative gene expression among four nonproducer cell lines stably transformed by oriP/BZLF1 plasmids.
Virology - 1 Oct 1990
Gradoville L, Grogan E, Taylor N, Miller G
Abstract excerpt
Lymphoid cell lines were established which stably carry the Epstein-Barr viral (EBV) BZLF1 gene on an extrachromosomal plasmid. These lines, which spontaneously synthesize the BZLF1 gene product, ZEBRA, were examined for expression of EBV genes which were activated by ZEBRA. Cell lines which acqu...
Topics
- Cell Line
- Cell Transformation, Viral
- DNA Replication
- DNA, Viral
- Drug Resistance, Microbial
- Gene Expression Regulation, Viral
- Genetic Complementation Test
- Herpesvirus 4, Human
- Humans
- Mutation
- Plasmids
- RNA, Messenger
- Trans-Activators
- Transcription, Genetic
- Virus Replication