Article
Pediatric celiac disease in India is associated with multiple DR3-DQ2 haplotypes.
Human immunology - 1 Aug 2002
Kaur Gurvinder, Sarkar N, Bhatnagar S, Kumar S, Rapthap C C, Bhan M K, Mehra N K
Abstract excerpt
The role of human leukocyte antigen (HLA) DQ2 heterodimer (DQA1*0501-DQB1*0201) in presenting gluten peptides to effector T cells in celiac disease (CD) has been well documented. Because HLA-DQ2 is carried on DR3 haplotypes due to linkage disequilibrium, such haplotypes are encountered more frequently in patients with autoimmune disease. This study analyzed 35 North Indian children below 15 years of age and...
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