Article
HLA-DRB1*12 is associated with protection against complicated typhoid fever, independent of tumour necrosis factor alpha.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Aug 2002
Dharmana E, Joosten I, Tijssen H J, Gasem M H, Indarwidayati R, Keuter M, Dolmans W M V, Van Der Meer J W M
Abstract excerpt
We investigated whether HLA-DR2 or -DR12 alleles in 63 Javanese patients with complicated or non-complicated typhoid fever were associated with severity of disease. No association was observed between HLA type and susceptibility to disease. However, in patients we did find a negative association of DR12 (DRB1*12021) with complicated typhoid fever (P = 0.05; OR = 0.3; 95% CI: 0.1-1.0). No effect of DR2 (DRB1*1502)...
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