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Article

The role of electrostatic interactions in human serum albumin binding and stabilization by halothane.

The Journal of biological chemistry - 27 Sept 2002

Liu Renyu, Pidikiti Ravindernath, Ha Chung-Eun, Petersen Charles E, Bhagavan Nadhipuram V, Eckenhoff Roderic G

Abstract excerpt

Electrostatic interactions have been proposed as a potentially important force for anesthetics and protein binding but have not yet been tested directly. In the present study, we used wild-type human serum albumin (HSA) and specific site-directed mutants as a native protein model to investigate the role of electrostatic interactions in halothane binding. Structural geometry analysis of the HSA-halothane complex...

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Source

Identifiers

PMID: 12118010
DOI: 10.1074/jbc.M205479200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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