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Article

Binding of warfarin, salicylate, and diazepam to genetic variants of human serum albumin with known mutations.

Molecular pharmacology - 1 Feb 1990

Kragh-Hansen U, Brennan S O, Galliano M, Sugita O

Abstract excerpt

Possible effects of single point mutations on the ligand-binding capabilities of human serum albumin (Alb) were investigated by studying the interactions between the strongly bound drugs warfarin, salicylate, and diazepam and five structurally characterized genetic variants of the protein. Equilibrium dialysis data, obtained with the variants and normal serum Alb, revealed pronounced reductions in high affinity...

Topics

Binding Sites
Dialysis
Diazepam
Humans
Mutation
Protein Binding
Radioligand Assay
Salicylates
Salicylic Acid
Serum Albumin
Structure-Activity Relationship

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Warfarin

Source

Identifiers

PMID: 2304452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2304452-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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