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Article

Distinct <i>in vivo</i> expression patterns of survivin splice variants in renal cell carcinomas

29 May 2002

Abstract excerpt

Survivin, a novel member of the inhibitor of apoptosis protein (IAP) family, reduces the susceptibility of tumor cells to proapoptotic stimuli, thereby promoting tumor cell survival during tumor progression and treatment with anticancer drugs. Recently, we identified 2 novel alternative splice variants of survivin, survivin-2B and survivin-Delta Ex3, which differ in their antiapoptotic properties. Survivin-2B has...

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PMID: 12115583
DOI: 10.1002/ijc.10450

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