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Article

Role of survivin splice variants in pediatric acute precursor B lymphoblastic leukemia.

Klinische Padiatrie - 1 Jan 2000

Tröger A, Siepermann M, Mahotka C, Wethkamp N, Bülle H, Laws H-J, Escherich G, Janka-Schaub G, Göbel U, Dilloo D

Abstract excerpt

BACKGROUND: Survivin, a member of the inhibitor of apoptosis protein (IAP) family is transiently expressed at low levels during normal hematopoesis but profoundly overexpressed in adult leukemia potentially contributing to leukemogenesis due to deregulated apoptosis and defective cell cycle control. Alternative splicing results in four different mRNA variants survivin, survivin2B, survivin-DeltaExon3 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17525905
DOI: 10.1055/s-2007-973850

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