Article
Expression of recombination activating genes 1 and 2 in peripheral B cells of patients with systemic lupus erythematosus.
Arthritis and rheumatism - 1 May 2002
Girschick Hermann J, Grammer Amrie C, Nanki Toshihiro, Vazquez Eduardo, Lipsky Peter E
Abstract excerpt
OBJECTIVE: To analyze immunoregulatory abnormalities in patients with systemic lupus erythematosus (SLE) by assessing the expression of messenger RNA (mRNA) for types 1 and 2 recombination activating genes (RAG) in the peripheral blood of patients with active SLE. METHODS: We examined B cell populations and also individual B cells from patients with SLE for the expression of RAG mRNA. RESULTS: Analysis of bulk...
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