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Article

The role of microRNA-1246 in the regulation of B cell activation and the pathogenesis of systemic lupus erythematosus

13 Mar 2015

Abstract excerpt

BACKGROUND: The pathogenesis of systemic lupus erythematosus (SLE) has not yet been completely elucidated. One of the hallmarks of SLE is the production of autoantibodies by uncontrolled over-activated B cells. Early B cell factor 1 (EBF1) contributes to the development, activation, and proliferation of B cells through activation of the AKT signaling pathway. Accumulating evidence has demonstrated that several...

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PMID: 25789080
DOI: 10.1186/s13148-015-0063-7

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