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Article

CD154–CD40 interactions mediate differentiation to plasma cells in healthy individuals and persons with systemic lupus erythematosus

1 Jun 2002

Abstract excerpt

Systemic lupus erythematosus (SLE) is a chronic, multisystem human autoimmune disease characterized by the differentiation of shortand long-lived plasma cells (PCs) that secrete pathogenic autoantibodies (1–3). These include autoantibodies specific for DNA involved in glomerulonephritis, autoantibodies to phospholipid 2glycoprotein I in thrombosis, and anti-Ro autoantibodies in congenital heart block. The exact...

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PMID: 12115170
DOI: 10.1002/art.10287

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