Article
A new allele of Gli3 and a new mutation, circletail (Crc), resulting from a single transgenic experiment.
Genesis (New York, N.Y. : 2000) - 1 Jun 2002
Rachel Rivka A, Wellington Sandra J, Warburton Dorothy, Mason Carol A, Beermann Friedrich
Abstract excerpt
While generating transgenic lines, transgene-linked mutations can occur, which are caused by an insertional mutation at a given locus. More rarely, mutations unlinked to the transgene insertion site are observed. In the process of generating a mouse overexpressing the enzyme tyrosinase, we have obtained one transgenic line that appears to carry a semidominant insertional mutation at the Gli3 (extra toes) locus,...
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