Article
Mini-mouse: disruption of the pygmy locus in a transgenic insertional mutant.
Science (New York, N.Y.) - 23 Feb 1990
Xiang X, Benson K F, Chada K
Abstract excerpt
A founder transgenic mouse harbored two different integration patterns of a transgene at the same locus, each of which gave rise to a similar autosomal recessive mutation. Mice of the mutant phenotype were of small stature but had normal levels of growth hormone. The disrupted locus was cloned, and a genetic and molecular analysis showed that the insertional mutants were allelic to a spontaneous mutant, pygmy....
Topics
- Animals
- Cloning, Molecular
- DNA
- Disease Models, Animal
- Dwarfism
- Female
- Growth Hormone
- Male
- Mice
- Mice, Mutant Strains
- Mice, Transgenic
- Mutation