Article
Induction of chondrogenesis in neural crest cells by mutant fibroblast growth factor receptors.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 2002
Petiot Anita, Ferretti Patrizia, Copp Andrew J, Chan Chi-Tsung Joseph
Abstract excerpt
Activating mutations in human fibroblast growth factor receptors (FGFR) result in a range of skeletal disorders, including craniosynostosis. Because the cranial bones are largely neural crest derived, the possibility arises that increased FGF signalling may predispose to premature/excessive skeletogenic differentiation in neural crest cells. To test this hypothesis, we expressed wild-type and mutant FGFRs in...
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