Article
Transdifferentiation of chicken embryonic cells into muscle cells by the 3' untranslated region of muscle tropomyosin.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1995
L'Ecuyer T J, Tompach P C, Morris E, Fulton A B
Abstract excerpt
Transfection with a plasmid encoding the 3' untranslated region (3' UTR) of skeletal muscle tropomyosin induces chicken embryonic fibroblasts to express skeletal tropomyosin. Such cells become spindle shaped, fuse, and express titin, a marker of striated muscle differentiation. Skeletal muscle tr...
Topics
- Animals
- Cell Differentiation
- Cells, Cultured
- Chick Embryo
- DNA, Complementary
- Fibroblasts
- Fluorescent Antibody Technique
- Gene Expression Regulation, Developmental
- Muscle, Skeletal
- Phenotype
- Transfection
- Tropomyosin