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Article

The role of substantia nigra pars reticulata in modulating clonic seizures is determined by testosterone levels during the immediate postnatal period.

Neurobiology of disease - 1 Jan 2007

Giorgi Filippo S, Velísková Jana, Chudomel Ondrej, Kyrozis Andreas, Moshé Solomon L

Abstract excerpt

GABAergic activation of substantia nigra pars reticulata (SNR) at postnatal day (PN) 15 has sex-specific features on seizure control in vivo and electrophysiological responses in vitro. In males, the GABA(A)-receptor agonist muscimol has proconvulsant effects and induces depolarizing responses. In females, muscimol has no effect on seizures and evokes hyperpolarizing responses. We determined the time period...

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Source

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Identifiers

PMID: 17011203
DOI: 10.1016/j.nbd.2006.08.009
PMCID: PMC1661598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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