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Article

Dose-Dependent Induction of Differential Seizure Phenotypes by Pilocarpine in Rats: Considerations for Translational Potential.

Medicina (Kaunas, Lithuania) - 26 Sept 2024

Vasović Dolika, Stanojlović Olivera, Hrnčić Dragan, Šutulović Nikola, Vesković Milena, Ristić Aleksandar J, Radunović Nebojša, Mladenović Dušan

Abstract excerpt

Background and Objectives: Pilocarpine is used in experimental studies for testing antiepileptic drugs, but further characterization of this model is essential for its usage in testing novel drugs. The aim of our study was to study the behavioral and EEG characteristics of acute seizures caused by different doses of pilocarpine in rats. Materials and Methods: Male Wistar rats were treated with a single...

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Identifiers

PMID: 39459366
DOI: 10.3390/medicina60101579
PMCID: PMC11509679

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