Article
Fidelity of the reverse transcriptase of human immunodeficiency virus type 2.
FEBS letters - 20 Jul 1992
Bakhanashvili M, Hizi A
Abstract excerpt
The relatively low fidelity of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) was implicated as a major factor that contributes to the genetic variability of the virus. Extension of mismatched 3' termini of the primer DNA was shown to be a major determinant of the infidelity of HIV-1 RT. Human immunodeficiency virus type 2 (HIV-2) also shows extensive genetic variations. Therefore, we have...
Topics
- Base Composition
- Base Sequence
- DNA, Viral
- DNA-Directed DNA Polymerase
- Genetic Variation
- HIV Reverse Transcriptase
- HIV-2
- Kinetics
- Molecular Sequence Data
- RNA-Directed DNA Polymerase