Article
The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell.
Experimental hematology - 1 Nov 2014
Shima Takahiro, Miyamoto Toshihiro, Kikushige Yoshikane, Yuda Junichiro, Tochigi Taro, Yoshimoto Goichi, Kato Koji, Takenaka Katsuto, Iwasaki Hiromi, Mizuno Shinichi, Goto Noriko, Akashi Koichi
Abstract excerpt
The cellular properties of leukemia stem cells (LSCs) are achieved at least through Class I and Class II mutations that generate signals for enhanced proliferation and impaired differentiation, respectively. Here we show that in t(8;21) acute myelogenous leukemia (AML), hematopoietic stem cells (HSCs) transform into LSCs via definitively-ordered acquisition of Class II (AML1/ETO) and then Class I (c-KIT mutant)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.