Article
Somatic mutations in the p53 gene account for the extension of replicative life span of macaque cells.
Biochemical and biophysical research communications - 19 Jul 2002
Shimizu Yuko, Ishida Takafumi
Abstract excerpt
To identify the underlying molecular bases that enable macaque cells to extend their replicative life span (RLS), somatic mutations in p53 were studied in two Japanese macaque (Macaca fuscata) and one long-tailed macaque (Macaca fascicularis) cell strains with extended RLS. Nucleotide sequences of the p53 whole coding region of each species were determined in early passaged cells and somatic mutations were...
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