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Complement C2 Receptor Inhibitor Trispanning Confers an Increased Ability to Resist Complement‐Mediated Lysis inTrypanosoma cruzi

9 Sept 2008

Abstract excerpt

The ability to resist complement differs between the Y and Colombiana Trypanosoma cruzi strains. We found that the Y strain of T. cruzi was more able to resist the classical and lectin pathways of complement activation than the Colombiana strain. The complement C2 receptor inhibitor trispanning gene (CRIT) is highly conserved in both strains. At the protein level, CRIT is expressed only in stationary-phase...

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PMID: 18781865
DOI: 10.1086/592167

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