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Article

Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes.

Oncogene - 11 Jul 2002

Cullingworth Jan, Hooper Martin L, Harrison David J, Mason John O, Sirard Christian, Patek Charles E, Clarke Alan R

Abstract excerpt

Mutations in the tumour suppressor genes SMAD4 (DPC4, deleted in pancreatic cancer locus 4) and adenomatous polyposis coli (APC) have been implicated in the development of pancreatic cancer in humans. Treatment of wild-type, Smad4(+/-), Apc(Min/+) or Apc(Min/+)Smad4(+/-) mice with N-Nitroso-N-Methyl Urea (NMU) results in abnormal foci in pancreatic acinar cells characterized by increased levels of beta-catenin....

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Source

Identifiers

PMID: 12096346
DOI: 10.1038/sj.onc.1205673

Genes

NMU
APC
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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