Article
Analysis of single nucleotide polymorphisms with solid phase invasive cleavage reactions.
Nucleic acids research - 15 Aug 2001
Wilkins Stevens P, Hall J G, Lyamichev V, Neri B P, Lu M, Wang L, Smith L M, Kelso D M
Abstract excerpt
Using microparticles as the capture surface and fluorescence resonance energy transfer as the detection technology, we have demonstrated the feasibility of performing the invasive cleavage reaction on a solid phase. An effective tool for many genomic applications, the solution phase invasive cleavage assay is a signal amplification method capable of distinguishing nucleic acids that differ by only a single base...
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