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Article

Long-term deprivation of substance P in PPT-A mutant mice alters the anoxic response of the isolated respiratory network.

Journal of neurophysiology - 1 Jul 2002

Telgkamp Petra, Cao Yuqing Q, Basbaum Allan I, Ramirez Jan-Marino

Abstract excerpt

The aim of this study was to elucidate the role of the neuromodulator substance P and its related tachykinin neurokinin A (NKA) in the homeostasis of respiratory activity. Respiratory activities, in form of fictive eupneic and sigh activities, were recorded extracellularly from the preBötzinger complex (PBC) in normoxic and anoxic conditions using medullary slice preparations. The effect of a blockade of...

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PMID: 12091546
DOI: 10.1152/jn.2002.88.1.206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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