Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxic ventilatory response in Tac1-/- neonatal mice following exposure to opioids.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Dec 2012

Berner J, Shvarev Y, Zimmer A, Wickstrom R

Abstract excerpt

Morphine is the dominating analgetic drug used in neonates, but opioid-induced respiratory depression limits its therapeutic use. In this study, we examined acute morphine effects on respiration during intermittent hypoxia in newborn Tac1 gene knockout mice (Tac1-/-) lacking substance P and neurokinin A. In vivo, plethysmography revealed a blunted hypoxic ventilatory response (HVR) in Tac1-/- mice. Morphine (10...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analgesics, Opioid
Share to Animals, Newborn
Share to Hypoxia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Morphine

Share to Motor Neurons

Share to Periodicity

Share to Pulmonary Ventilation

Share to Respiratory Mechanics

Source

Identifiers

PMID: 23065762
DOI: 10.1152/japplphysiol.00188.2012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxic ventilatory response in Tac1-/- neonatal mice following exposure to opioids.PMID 23065762Read ↗

The in vivo respiratory phenotype of the adenosine A1 receptor knockout mouse.Semantic proximity Read ↗

Impaired cardiorespiratory responses to hypercapnia in neonatal mice lacking PAC1 but not VPAC2 receptors.Semantic proximity Read ↗

Long-term deprivation of substance P in PPT-A mutant mice alters the anoxic response of the isolated respiratory network.Semantic proximity Read ↗

Caffeine improves the ability of serotonin-deficient (Pet-1-/-) mice to survive episodic asphyxia.Semantic proximity Read ↗

Subtle alterations in breathing and heart rate control in the 5-HT1A receptor knockout mouse in early postnatal development.Semantic proximity Read ↗

Transgenic models to study disorders of respiratory control in newborn mice.Semantic proximity Read ↗

Sudden neonatal death in PACAP-deficient mice is associated with reduced respiratory chemoresponse and susceptibility to apnoea.Semantic proximity Read ↗

Ventilatory responses to hypercapnia and hypoxia in heterozygous c-ret newborn mice.Semantic proximity Read ↗

Genesis of gasping is independent of levels of serotonin in the Pet-1 knockout mouse.Semantic proximity Read ↗

Brainstem serotonin deficiency in the neonatal period: autonomic dysregulation during mild cold stress.Semantic proximity Read ↗

Bradycardia in serotonin-deficient Pet-1-/- mice: influence of respiratory dysfunction and hyperthermia over the first 2 postnatal weeks.Semantic proximity Read ↗

The Ventilatory Response to Hypoxia in Mammals: Mechanisms, Measurement, and AnalysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.