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Article

Apoptosis Underlies Immunopathogenic Mechanisms in Acute Silicosis

1 Jul 2002

Abstract excerpt

We investigated immunopathogenic roles for apoptosis in acute murine silicosis. Intratracheal silica instillation induced pulmonary inflammation and enlarged thoracic lymph nodes. Lymphocytes from silica-exposed lymph nodes showed reduced mitogenic responses to T cell receptor (TCR) stimulation, and markedly increased activation-induced cell death, compared with control lymphocytes from saline-exposed lymph...

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Identifiers

PMID: 12091249
DOI: 10.1165/ajrcmb.27.1.4717

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