Article
Pathological findings in human autoimmune lymphoproliferative syndrome.
The American journal of pathology - 1 Nov 1998
Lim M S, Straus S E, Dale J K, Fleisher T A, Stetler-Stevenson M, Strober W, Sneller M C, Puck J M, Lenardo M J, Elenitoba-Johnson K S, Lin A Y, Raffeld M, Jaffe E S
Abstract excerpt
The defects in lymphocyte apoptosis that underlie the autoimmune lymphoproliferative syndrome (ALPS) are usually attributable to inherited mutations of the CD95 (Fas) gene. In this report, we present the histopathological and immunophenotypic features seen in the lymph nodes (n = 16), peripheral blood (n = 10), bone marrow (n = 2), spleen (n = 3), and liver (n = 2) from 10 patients with ALPS. Lymph nodes showed...
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