Article
The mRNA structure has potent regulatory effects on type 2 iodothyronine deiodinase expression.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 2002
Gereben Balázs, Kollár Anna, Harney John W, Larsen P Reed
Abstract excerpt
Type 2 deiodinase (D2) is a selenoenzyme catalyzing the activation of T(4) to T(3). D2 activity/mRNA ratios are often low, suggesting that there is significant posttranscriptional regulation. The D2 mRNA in higher vertebrates is more than 6 kb, containing long 5' and 3' untranslated regions (UTRs). The D2 5'UTRs are greater than 600 nucleotides and contain 3-5 short open reading frames. These full-length 5'UTRs...
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