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Article

Differential effect of NF‐κB activity on β‐catenin/Tcf pathway in various cancer cells

31 Jan 2008

Abstract excerpt

beta-Catenin/Tcf and NF-kappaB pathways play an important role in biological functions. We determined the underlying mechanisms of differential interaction between two pathways in various human cancer cell lines. NF-kappaB positively regulated beta-catenin/Tcf pathways in human glioblastoma, whereas it has an opposite effect on beta-catenin/Tcf pathways in colon, liver, and breast cancer cells. Expression of...

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PMID: 18242184
DOI: 10.1016/j.febslet.2008.01.029

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