Article
No evidence for involvement of the calpain-10 gene 'high-risk' haplotype combination for non-insulin-dependent diabetes mellitus in early onset obesity.
Molecular genetics and metabolism - 1 Jun 2002
Hinney Anke, Antwerpen Benjamin, Geller Frank, Schäfer Helmut, Siegfried Wolfgang, Goldschmidt Hanspeter, Remschmidt Helmut, Ziegler Andreas, Hebebrand Johannes
Abstract excerpt
In light of evidence of linkage of obesity to chromosome 2q31-q37, we hypothesized that the calpain-10 gene 'high-risk' haplotype combination for non-insulin-dependent diabetes mellitus (NIDDM) is involved in early onset obesity. We screened the NIDDM 'high-risk'-haplotype combination formed by the alleles 112 and 121 of the polymorphisms UCSNP-43, -19, and -63 in 166 families consisting of an extremely obese...
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