Article
Membrane structure of the human immunodeficiency virus gp41 fusion domain by molecular dynamics simulation.
Biophysical journal - 1 Jul 2002
Kamath Shantaram, Wong Tuck C
Abstract excerpt
The structures of the 16-residue fusion domain (or fusion peptide, FP) of the human immunodeficiency virus gp41 fusion protein, two of its mutants, and a shortened peptide (5-16) were studied by molecular dynamics simulation in an explicit palmitoyloleoylphosphoethanolamine bilayer. The simulations showed that the active wild-type FP inserts into the bilayer approximately 44 degrees +/- 6 degrees with respect to...
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