Article
Fusing simulation and experiment: The effect of mutations on the structure and activity of the influenza fusion peptide.
Scientific reports - 15 Jun 2016
Lousa Diana, Pinto Antónia R T, Victor Bruno L, Laio Alessandro, Veiga Ana S, Castanho Miguel A R B, Soares Cláudio M
Abstract excerpt
During the infection process, the influenza fusion peptide (FP) inserts into the host membrane, playing a crucial role in the fusion process between the viral and host membranes. In this work we used a combination of simulation and experimental techniques to analyse the molecular details of this process, which are largely unknown. Although the FP structure has been obtained by NMR in detergent micelles, there is...
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