Article
[Implication of single nucleotide polymorphisms in association study: mitochondrial variations as another genetic markers for hypertension].
Rinsho byori. The Japanese journal of clinical pathology - 1 May 2002
Shoji Masaru, Tsutaya Shoji, Kasai Takeshi, Yasujima Minoru
Abstract excerpt
Although multiple nuclear gene polymorphisms have been identified as potential risk factors for hypertension, the linkage between extranuclear DNA variations and hypertension has been uncertain. We investigated whether mitochondrial DNA(mtDNA) polymorphisms are implicated in Japanese hypertension. We used direct sequencing methods to search for single nucleotide polymorphisms(SNPs) in a hypervariable segment of...
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