Article
Geographical variation in the penetrance of CDKN2A mutations for melanoma.
Journal of the National Cancer Institute - 19 Jun 2002
Bishop D Timothy, Demenais Florence, Goldstein Alisa M, Bergman Wilma, Bishop Julia Newton, Bressac-de Paillerets Brigitte, Chompret Agnès, Ghiorzo Paola, Gruis Nelleke, Hansson Johan, Harland Mark, Hayward Nicholas, Holland Elizabeth A, Mann Graham J, Mantelli Michela, Nancarrow Derek, Platz Anton, Tucker Margaret A
Abstract excerpt
BACKGROUND: Germline mutations in the CDKN2A gene, which encodes two proteins (p16INK4A and p14ARF), are the most common cause of inherited susceptibility to melanoma. We examined the penetrance of such mutations using data from eight groups from Europe, Australia and the United States that are part of The Melanoma Genetics Consortium. METHODS: We analyzed 80 families with documented CDKN2A mutations and multiple...
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