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Article

Analysis of a temperature-sensitive mutant rotavirus indicates that NSP2 octamers are the functional form of the protein.

Journal of virology - 1 Jul 2002

Taraporewala Zenobia F, Schuck Peter, Ramig Robert F, Silvestri Lynn, Patton John T

Abstract excerpt

Evidence that NSP2 plays a role in packaging and replication comes from studies on tsE(1400), a rotavirus mutant with a temperature-sensitive (ts) lesion in the NSP2 gene. Cells infected with tsE and maintained at nonpermissive temperature contain few replication-assembly factories (viroplasms) or replication intermediates and produce virus particles that are mostly empty. Sequence analysis has indicated that an...

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Identifiers

PMID: 12072508
DOI: 10.1128/jvi.76.14.7082-7093.2002
PMCID: PMC136338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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