Analysis of a temperature-sensitive mutant rotavirus indicates that NSP2 octamers are the functional form of the protein.

doi:10.1128/jvi.76.14.7082-7093.2002

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Analysis of a temperature-sensitive mutant rotavirus indicates that NSP2 octamers are the functional form of the protein.

Journal of virology - 1 Jul 2002

Taraporewala Zenobia F, Schuck Peter, Ramig Robert F, Silvestri Lynn, Patton John T

Abstract excerpt

Evidence that NSP2 plays a role in packaging and replication comes from studies on tsE(1400), a rotavirus mutant with a temperature-sensitive (ts) lesion in the NSP2 gene. Cells infected with tsE and maintained at nonpermissive temperature contain few replication-assembly factories (viroplasms) or replication intermediates and produce virus particles that are mostly empty. Sequence analysis has indicated that an...

Topics

Cell Line
Mutation
Protein Conformation
Protein Structure, Quaternary
RNA, Viral
RNA-Binding Proteins
Recombination, Genetic
Rotavirus
Temperature
Ultracentrifugation
Viral Nonstructural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 12072508
DOI: 10.1128/jvi.76.14.7082-7093.2002
PMCID: PMC136338

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics