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Article

Retroviral transduction of IL2RG into CD34(+) cells from X-linked severe combined immunodeficiency patients permits human T- and B-cell development in sheep chimeras.

Blood - 1 Jul 2002

Tsai Emily J, Malech Harry L, Kirby Martha R, Hsu Amy P, Seidel Nancy E, Porada Christopher D, Zanjani Esmail D, Bodine David M, Puck Jennifer M

Abstract excerpt

X-linked severe combined immunodeficiency (XSCID) is caused by mutations of the common gamma chain of cytokine receptors, gamma(c). Because bone marrow transplantation (BMT) for XSCID does not provide complete immune reconstitution for many patients and because of the natural selective advantage conferred on lymphoid progenitors by the expression of normal gamma(c), XSCID is a good candidate disease for...

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Share to Antigens, CD34
Share to Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Interleukin-2

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Source

Identifiers

PMID: 12070011
DOI: 10.1182/blood.v100.1.72

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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