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Article

Gene therapy improves immune function in preadolescents with X-linked severe combined immunodeficiency.

Blood - 1 Jul 2007

Chinen Javier, Davis Joie, De Ravin Suk See, Hay Beverly N, Hsu Amy P, Linton Gilda F, Naumann Nora, Nomicos Effie Y H, Silvin Christopher, Ulrick Jean, Whiting-Theobald Narda L, Malech Harry L, Puck Jennifer M

Abstract excerpt

Retroviral gene therapy can restore immunity to infants with X-linked severe combined immunodeficiency (XSCID) caused by mutations in the IL2RG gene encoding the common gamma chain (gammac) of receptors for interleukins 2 (IL-2), -4, -7, -9, -15, and -21. We investigated the safety and efficacy of gene therapy as salvage treatment for older XSCID children with inadequate immune reconstitution despite prior bone...

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Identifiers

PMID: 17369490
DOI: 10.1182/blood-2006-11-058933
PMCID: PMC1896128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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